Immunoglobulin Lambda 2 (Igl2)

Iglc2; Ig lambda-2 chain C region; immunoglobulin lambda constant 2; Kern-Oz- marker

SPN	A900
HGNC	5856
MGI	99547
UniProt	P0CG05
Wiki	IGLC2

Immunoglobulin lambda locus is a region on human chromosome 22 that contains genes for the lambda light chains of antibodies (or immunoglobulins). Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. The PCR products of the antigen binding exons of the chicken IgL and IgH chains then were cloned into expression vectors that contained the murine Igλ2 light chain gene or the murine IgGγ1 heavy chain gene. These expression plasmids had been modified to have directional cloning sites that allowed the direct replacement of the mouse VJ or VDJ by the chicken VJ or VDJ segment.

Reference

"Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein."
Biochem. J. 110:631-652(1968) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges."
J. Biol. Chem. 245:2171-2176(1970) [PubMed] [Europe PMC] [Abstract]

"Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation."
Hoppe-Seyler's Z. Physiol. Chem. 352:247-266(1971) [PubMed] [Europe PMC] [Abstract]

"Clustered arrangement of immunoglobulin lambda constant region genes in man."
Nature 294:536-540(1981) [PubMed] [Europe PMC] [Abstract]

"Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup."
J. Biochem. 93:421-429(1983) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of the human immunoglobulin lambda genes."
J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract]

"One-megabase sequence analysis of the human immunoglobulin lambda gene locus."
Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]

"Immunoglobulin lambda (IGL) genes of human and mouse."
(In) Honjo T., Alt F.W., Neuberger M. (eds.);Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2004)