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Prostatitis is inflammation of the prostate gland. Prostatitis is classified into acute, chronic, asymptomatic inflammatory prostatitis, and chronic pelvic pain syndrome. The term prostatitis refers, in its strictest sense, to histological inflammation of the tissue of the prostate gland. Like all forms of inflammation, it can be associated with an appropriate response of the body to an infection, but it also occurs in the absence of infection.

Nonbacterial prostatitis is a common clinical entity which is often difficult to diagnose and treat. To develop an animal model and characterize the immune parameters of nonbacterial prostatitis. Studies demonstrated the prostatic inflammation to be at least in part immune mediated. It was conclude that injection of syngenic prostate antigen induces prostatic inflammation similar to clinical nonbacterial prostatitis.