Kaschin-Beck Disease (KBD)
Kashin–Beck disease (KBD) is a chronic, endemic type of osteochondropathy. KBD usually involves children ages 5–15. To date, more than a million individuals have suffered from KBD. The symptoms of KBD include joint pain, morning stiffness in the joints, disturbances of flexion and extension in the elbows, enlarged inter-phalangeal joints and limited motion in many joints of the body. Death of cartilage cells in the growth plate and articular surface is the basic pathologic feature; this can result in growth retardation and secondary osteoarthrosis. A model for rat Kashin-Beck disease induced by employing T-2 toxin treatment under selenium deficient conditions was established by researchers. Studies showed that increasing TBARS and decreasing antioxidants in serum and cartilage by T-2 toxin treatment with a selenium-deficient nutritional status may alter oxidative stress in joint tissues and contribute to the pathological process of cartilage damage in KBD.
Organism species: Pan-species (General)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | N/A | Recombinant Kaschin-Beck Disease (KBD) | Antigenic Transformation Customized Service Offer |
Antibodies | N/A | Monoclonal Antibody to Kaschin-Beck Disease (KBD) | Monoclonal Antibody Customized Service Offer |
N/A | Polyclonal Antibody to Kaschin-Beck Disease (KBD) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | N/A | CLIA Kit for Kaschin-Beck Disease (KBD) | CLIA Kit Customized Service Offer |
N/A | ELISA Kit for Kaschin-Beck Disease (KBD) | ELISA Kit Customized Service Offer |