Cold Injury (CI)

Cold injury or frostbite is the medical condition in which localized damage is caused to skin and other tissues due to freezing. Frostbite is most likely to happen in body parts farthest from the heart and those with large exposed areas. The initial stages of frostbite are sometimes called frostnip.

Cold injury in mice provides a simple animal model to study the pathogenesis of brain edema and apoptosis in genetically altered animals.The model for cold injury can also be used to research the blood–brain barrier and cerebral angiogenesis.

Frostbite is diagnosed based on signs and symptoms as described above, and by patient history.