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Myasthenia Gravis (MG)

Myasthenia gravis (MG) is a long term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. Onset can be sudden. Those affected often have a large thymus gland or develop a thymoma.

Myasthenia gravis is an autoimmune disease which results fromantibodies that block or destroy nicotinic acetylcholine receptorsat the junction between the nerve and muscle. This prevents nerve impulses from triggering muscle contractions. Rarely an inherited genetic defect in the neuromuscular junction results in a similar condition known as congenital myasthenia.