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Epidermoid Carcinoma Cells (EC)

Ca Ski; ME-180; A-253; HLF-a;A431;Calu-1; MS751; A388

Epidermoid carcinoma cells are used in biomedical research. More specifically, they are used in studies of the cell cycle and cancer-associated cell signalling pathways since they express abnormally high levels of the Epidermal growth factor receptor (EGFR).

As such they are often used as a positive control for EGFR expression. They contain no functional p53, a potent tumor suppressor gene, and so are highly sensitive to mitogenic stimuli. A431 cells were established from an epidermoid carcinoma in the skin/epidermis of an 85- year-old female patient.