Adenosine Kinase (ADK)

AK; Adenosine 5'-Phosphotransferase

SPN	U564
HGNC	257
MGI	87930
PubMed	14736855
RGD	2046
UniProt	P55263
Wiki	ADK

Adenosine kinase is an adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides.

Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2 for activity.

Reference

"Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases."
Proc. Natl. Acad. Sci. U.S.A. 93:1232-1237(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene."
Eur. J. Biochem. 241:564-571(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of the adenosine kinase gene from rat and human tissues."
Biochem. Biophys. Res. Commun. 231:645-650(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus."
Biochem. Biophys. Res. Commun. 388:46-50(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of human adenosine kinase at 1.5-A resolution."
Biochemistry 37:15607-15620(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of the phosphotyrosine proteome from thrombin activated platelets."
Proteomics 2:642-648(2002) [PubMed] [Europe PMC] [Abstract]

"Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function."
Am. J. Hum. Genet. 89:507-515(2011) [PubMed] [Europe PMC] [Abstract]