Pim-2 Oncogene (PIM2)

Serine/threonine-protein kinase pim-2

SPN	K256
HGNC	8987
MGI	97587
PubMed	19841674
UniProt	Q9P1W9
Wiki	PIM2

PIM2 encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. The deduced 334-amino acid sequence of the clone showed 90% identity with the mouse Pim2 protein. Like mouse Pim2, the human protein appears to be a serine threonine kinase. Northern blot analysis detected 2 PIM2 transcripts. A 2.2-kb transcript was expressed in all tissues tested, but most abundantly in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It was also highly expressed in human leukemic and lymphoma cell lines and a colorectal adenocarcinoma cell line. A 5.0-kb transcript was expressed only in spleen, thymus, small intestine, colon, and in very small amounts in peripheral blood leukocytes.

Reference

"The human Pim-2 proto-oncogene and its testicular expression."
Biochim. Biophys. Acta 1442:274-285(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]

"Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels."
Cancer Res. 68:5076-5085(2008) [PubMed] [Europe PMC] [Abstract]

"Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell."
J. Surg. Res. 153:17-22(2009) [PubMed] [Europe PMC] [Abstract]

"Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells."
Int. J. Biochem. Cell Biol. 42:1030-1038(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor."
PLoS ONE 4:E7112-E7112(2009) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]