Adropin (AD)

ENHO; UNQ470; Energy Homeostasis Associated Protein

SPN	G242
HGNC	24838
MGI	1916888
PubMed	20837912
UniProt	Q6UWT2

Adropin, a recently described endogenous neuroendocrine peptide, has been suggested to play a critical role in modulating normal physiological processes and maintaining metabolic homeostasis. Adropin (10 ng/mL) caused a marked 10-fold increase in endothelial cell migration and proliferation and significantly increased capillary-like endothelial cell sprouting and tube formation (p<0.001).

In mice,the liver produces a protein called adropin, which rises in response to high-fat foods and falls after fasting. The protein seems to play a role in governing the activity of other metabolic genes, particularly those involved in the production of lipids from carbohydrates. Studies of the protein in obese animals suggest that it also plays a role in insulin response and in preventing the buildup of fat in the liver.

Reference

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism."
Cell Metab. 8:468-481(2008) [PubMed] [Europe PMC] [Abstract]