Nitric Oxide Inducible Gene Protein (NOXIN)

DDIAS; C11orf82; Chromosome 11 Open Reading Frame 82; DNA damage-induced apoptosis suppressor protein

SPN	D563
HGNC	26351
MGI	1921291
PubMed	17515607
UniProt	Q8IXT1

NOXINActs as an anti-apoptotic factor and its absence increases cell death under normal and stress conditions. Can induce cell cycle arrest in the G1 or early S phase and this activity is independent of p53/TP53.

Chromosome 11 is one of the 23 pairs of chromosomes in humans. Humans normally have two copies of this chromosome. Chromosome 11 spans about 134.5 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells. It is one of the most gene- and disease-rich chromosomes in the human genome. Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma."
Int. J. Cancer 134:2595-2604(2014) [PubMed] [Europe PMC] [Abstract]