Tyrosine Protein Kinase 7 (PTK7)
CCK4; Protein Tyrosine Kinase 7; Colon Carcinoma Kinase 4; Inactive tyrosine-protein kinase 7; Pseudo tyrosine kinase receptor 7
Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene an intracellular domain with tyrosine kinase homology and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.
PTK7 serves as a context-dependent signalling switch for the Wnt pathways (particularly in planar cell polarity related functions such as convergent extension and neural crest cell migration) and appears to have similar functions for plexin and Flt-1 pathways.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Hu01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Hu01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Hu01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Hu01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Hu01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Mu01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Mu01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Mu01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Mu01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Mu01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Ra01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Ra01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Ra01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Ra01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Ra01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Ca01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Ca01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Ca01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Ca01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Ca01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Po01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Po01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Po01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Po01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Po01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Bo01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Bo01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Bo01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Bo01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Bo01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Rb01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Rb01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Rb01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Rb01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Rb01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPA458Mo01 | Recombinant Tyrosine Protein Kinase 7 (PTK7) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAA458Mo01 | Monoclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IP. |
| PAA458Mo01 | Polyclonal Antibody to Tyrosine Protein Kinase 7 (PTK7) | WB; IHC; ICC; IF. | |
| Assay Kits | CLA458Mo01 | CLIA Kit for Tyrosine Protein Kinase 7 (PTK7) | CLIA assay for Antigen Detection |
| ELA458Mo01 | ELISA Kit for Tyrosine Protein Kinase 7 (PTK7) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family."
Oncogene 11:2179-2184(1995) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG."
J. Biochem. 119:235-239(1996) [PubMed] [Europe PMC] [Abstract]
"Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA."
Biochim. Biophys. Acta 1579:153-163(2002) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesis."
Biochem. Biophys. Res. Commun. 371:793-798(2008) [PubMed] [Europe PMC] [Abstract]
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
"The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcome."
Blood 116:2315-2323(2010) [PubMed] [Europe PMC] [Abstract]
"The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis."
J. Biol. Chem. 285:35740-35749(2010) [PubMed] [Europe PMC] [Abstract]
"Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway."
PLoS ONE 5:E14018-E14018(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Protein tyrosine kinase 7 has a conserved role in Wnt/beta-catenin canonical signalling."
EMBO Rep. 12:43-49(2011) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]